Sunday, April 08, 2012

 NEUROBEHAVIORAL TOXICOLOGICAL ANALYSIS OF A RAMPAGE KILLER

Raymond Singer, Ph.D.
Independent Practice
Santa Fe, New Mexico
and
New York, New York
www.neurotox.com
ray.singer@gmail.com

and

Jack Dwayne Thrasher, Ph.D.
Independent Practice
Citrus Grove, California

Published until April 15, 2012  at: http://neurotox.blogspot.com/

Abstract

In September 2008, a 28-year-old man went on a shooting rampage that left six people dead and four others wounded. Upon arraignment, he told the judge that God told him to kill. The evaluation was conducted to determine if exposure to various neurotoxic agents impacted the defendant's sanity.

Methods: Review of records (criminal, educational, historical, medical, toxicological), diagnostic neuro-psychological interview, family members interview, police reports, and administration of neuropsychological/ behavioral tests.

Results: The defendant had a history of exposure to multiple neurotoxic substances. He lived in a new formaldehyde emitting mobile home from birth to age 14 with psychomotor symptoms. In 2001-2007, he worked as a union painter with resulting headaches and other symptoms. By 2003, there were reports of hallucinations. From 2006-2008, he lived in an extremely moldy trailer. Sampling of the trailer in 2009 found numerous ERMI moldiness index samples were at Level 4, showing the greatest likelihood of having a mold problem; mold and mycotoxin samples found 30.5 ppb trichothecenes; 57 ng/sample LSD from ergotomines in the ceiling, 86 ng on bed pillow; 28.9 ppb ochratoxin A on mattress cover; 14 ppb ochratoxin A in the defendant's urine. In April 2008, he had overdosed dermal exposure to pyrethroids for treating probably hallucinated lice.

Neuropsychological testing post-offense (April, 2009) found IQ at the 42%tile; Working Memory, 1%tile; Processing Speed 27%tile; Visual Immediate Memory 7%tile; Booklet Category Test  11%tile; Trailmaking 1%tile; and other findings. Borderline Personality Disorder was identified by the NEO-3. Multiple tests for malingering, including the TOMM, were negative.

Conclusion: Significant mental illness was found, with neuropsychological results consistent with adult-onset neurotoxicity, including mycotoxicosis. The defendant was found not guilty by reason of insanity on some counts, guilty on other counts, spared the death penalty, committed to a mental hospital until cured, and then to prison for life.

The subject was at heightened risk of neurotoxicity from significant exposure to formaldehyde, solvents, products of repeated indoor water intrusion - including mold and mycotoxins (including lysergic acid diethylamide (LSD) resulting from mold in the defendant’s residence) - and pesticides. The additive or synergistic effects of these exposures rendered him delusional, with significant impairment of cognitive, emotional and executive function. Neuropsychological testing was consistent with these impairments. 

The defendant suffered from an undiagnosed mental disorder as a child, involving social and cognitive dysfunction. He had significant formaldehyde exposure as a fetus and child. He had a difficult upbringing in his home, was functioning somewhat successfully given his circumstances until exposed to a series of toxic chemicals as a painter, at which time his mental health deteriorated -  from the solvent neurotoxicity insult- which permanently sent him into a downward spiral of deteriorating mental health.

As his mental health deteriorated, during 2006-2008,  the defendant lived in a very moldy trailer, with environmental LSD exposure from the mycotoxins produced by mold. In his delusional state, he acquired and probably overdosed with pesticides for lice and bedbugs, which would exacerbate his pre-existing mental illness, and result in an acute delusional and confusional state.

The defendant may be viewed as having an underlying thought disorder, such as schizophrenia, which was exacerbated by neurotoxicity from various sources, resulting in delusional psychosis at the time of the shooting.

Mold exposure in the trailer

The extensive moldy condition of the residence was caused by repeated indoor water intrusion. Per environmental inspection, the shingles on roof were faulty, allowing rain to pour in. Among numerous surfaces, the ceiling was extensively moldy. The unit had been moldy since being purchased, with sick previous occupants. See color photographs.
  
Mold exposure lab reports

Environmental Relative Moldiness Index (ERMI) Report: 3/20/2009. ERMI interpretation: the ERMI takes into account both the quantity of each mold species and the diversity of species present. It measures the long term mold burden. ERMI Level 2 are less likely to have a mold problem; ERMI Level  3 are more likely to have a mold problem; ERMI Level 4 have the greatest likelihood of having a mold problem.

Insulation Ceiling: ERMI Level 2
Bedroom Closet: ERMI Level 4
Pillowcase: ERMI Level 4
Mattress Cover: ERMI Level 4
Kitchen Ceiling: ERMI Level 4
Ceiling over Sink: ERMI Level 3

Mycotoxin Testing     Note:  All Mycotoxins are reported in parts per billion (ppb)                                TRICOTHECENES     AFLATOXINS     OCHRATOXIN A
                        
    Ceiling Insulation over Bed              30.463            3.5        2.8
    Ceiling Tile Above Kitchen Sink             0            0        9.1
    Kitchen Ceiling                  0            0        4.9
    Plastic and Insulation Bedroom   closet     0.901            2.1        9.8
    Pillow cover                     0            1.4        9.8
    Mattress Cover                  0            0        28.9
    Urine (defendant)                 Not Present         Not Present     14


Trailer Testing                    
15-Mar-09            FUNGAL CULTURES       
Received in lab 17 Mar 09               
Refer to COC forms                
            Living Room     R0309031    Penicillium sp.
                    Scopulariopsis sp.
                    Aspergillus sp
            Bedroom Closet     R0309032    Scopulariopsis sp.
                    Rhizopus sp
                    Penicillium sp.
                    Aspergillus sp
            Bedroom     R0309033    Scopulariopsis sp.
                    Penicillium sp.
                    Aspergillus sp
            Front Seat - Van     R0309034    Penicillium sp.
                    Aspergillus sp
            Kitchen Baby High Chair    R0309034    Scopulariopsis sp.
                    Penicillium sp.
                    Rhizopus sp. 
                    Aspergillus sp
            Van Rear Seat     R0309035    Penicillium sp.
                    Aspergillus sp
                    Cladasporium sp.






Ergotamines: After acidic extractions of the samples, the specimens were found to contain lysergic acid  (LSD) in the samples taken from the ceiling over the bed (57 ng/sample) and the pillow from the bed (86  ng/sample)

Neurobehavioral test results

Age:            28
Gender:        Male
Race:            White
Height:        6' 00"
Weight:        170
Education:        Per parents: dropped out of school as a sophomore at age 15. Educational record review: high school transcript: In 9th  and 10th grade, the subject received quite a number of A's, including in subjects such as science, art, physical education, health, occupational education, science, and biology. His grades included A's in Library Science.
Marital status:        Never married             
Children:        0
Occupation:        Mechanic, painter   

Premorbid IQ Estimates:  Based on a demographic formula which considers current vocabulary scores, education, and occupation, expected pre-morbid IQ would be approximately:

            Score        Percentile      SEe
    Full Scale    112        75        8.64

Cognitive Testing Standard: Scores significantly below the standard are considered abnormal for the subject and deficit.
                    Scaled Score        Cutoff
    IQ        Percent    equiv.        Scaled/Percentile
    112        75        12            8/25

Wechsler Adult Intelligence Scale, Third Edition: WAIS-III:
                Age - Adjusted
                Scaled Scores        Percentile   
Verbal Subscales       
    Vocabulary            13        84   
    Similarities            10        50   
    Arithmetic                7          16   
    Digit Span               4          2   
    Information              14          91
    Comprehension          9        37   
    Letter-Number
      Sequencing               3            1

Performance Subscales
    Picture Completion        11        63
    Digit Symbol - Coding      8        25
    Block Design            10        50
    Matrix Reasoning        11        63
    Picture Arrangement          9        37
    Symbol Search          9        37
    Object Assembly          9        37

    Score    Percentile    Confidence Interval - 95%

    Verbal IQ:            96        39        91 – 101
    Performance IQ:        98        45        91 – 105
    Full Scale IQ:            97        42        93 – 101
Index Scores:
Verbal Comprehension        112        79        106 – 117
Perceptual Organization        103        58        96 – 110
Working Memory             67         1        62 – 76   
Processing Speed             91        27        83 – 101

Discrepancy Comparisons: Statistical significance 0.05 level
                Frequency of Difference in Standardization
                        Difference    Sample
Verbal Comprehension - Working Memory    45        0.5
Verbal Comprehension – Processing Speed    21        17

Interpretation: A decline in cognitive functioning was detected, particularly affecting Working Memory, at the 1st percentile and Processing speed at the 27th percentile. This was further reflected in the contrast between the Verbal Comprehension Index and the Working Memory Index, as well as the Verbal Comprehension Index and the Processing Speed Index, with a statistically very infrequent spread between the two indexes. This finding suggests that there has been a decline affecting working memory and processing speed, consistent with patients with diagnosed neurotoxicity.

Further analysis shows that attentional skills have been compromised, with Digit Span at the 2nd  percentile, Letter Number Sequencing at the 1st percentile, and Digit Symbol -- Coding at the 25th percentile.

These findings are consistently with patients with diagnosed neurotoxicity.

Wechsler Memory Scale, Third Edition (WMS-III):

Primary Subtests                Age Scaled Score    Percentile
Logical Memory I - Recall              8             25
Faces I - Recognition                    9            37
Verbal Paired Assoc. I - Recall          9            37
Family Pictures I - Recall              2            <1
Letter-Number Sequencing              3              1
Spatial Span                    10            50
Logical Memory II - Recall              9            37
Faces II - Recognition            12            75
Verbal Paired Assoc. II - Recall        13            84
Family Pictures II - Recall              2            <1
Auditory Recognition - Delayed        10            50

Auditory Process Subtests
Logical Memory I               
    1st Recall Total              9            37
    Learning Slope              8            25
Verbal Paired Assoc. I
    1st Recall Total              8            25
    Learning Slope            12            75
Logical Memory II
    Percent Retention            10            50
Verbal Paired Assoc. II   
    Percent Retention            12            75

                                                Confidence
Primary Index Scores        Index Score    Percentile    Interval (95%)
    Auditory Immediate           92          30         85 – 100   
    Visual Immediate          71          3        66 – 86
    Immediate Memory          78          7        72 – 88
    Auditory Delayed        105        63        95 – 114
    Visual Delayed          81        10        74 – 94
    Auditory Recog. Delayed    100        50        89 – 111
    General Memory          93        32        86 – 102   
    Working Memory          81         10           74 – 93

Interpretation: Memory deficits primarily affecting Visual (Immediate and Delayed) and  Working Memory. Memory deficits are consistent with patients with diagnosed neurotoxicity.

Benton Visual Retention Test (Administration B, Form C). Comparison IQ = 112
            Expected for IQ    Observed  Difference
Number correct    8 - 1 =  7         3         4               
Number errors    2 + 2 = 4        16         12   
               
Interpretation:
Number correct score: Suggested acquired impairment of cognitive functioning.
Number of errors score: Strong indication of acquired impairment of cognitive functioning

The Booklet Categories Test (CT):  
Subtest    Raw Score   
I Errors          0
II Errors          0
III Errors        35
IV Errors          2
V Errors           9
VI Errors           9
VII Errors          5       
                T-score    Percentile
Total Errors    60        38        11

Interpretation: Impaired abstraction or concept formation ability, flexibility in the face of complex and novel problem-solving, and capacity to learn from experience, indicative of brain damage.

Comprehensive Trail-Making Test (CTMT):

Trail #    Raw Score    T-Score    Percentile
1        26                56        72
2        29                52        57       
3        41                41        18
4        26                50        50
5        106                22         <1   
                       
Interpretation: Deficit on the critical trail #5.

Controlled Oral Word Association Test evaluates verbal fluency, the ability to find and use words.

Raw Score    Correction    Total    Percentile
30                3        33        27   
Interpretation:    Borderline or possible deficit

Embedded Figures Test evaluates the ability to detect visual figure-ground relationships (the use of the eyes to make sense out of what the eye sees).

Number detected out of 40 objects: 37
Interpretation: Within normal limits

Frontal Systems Behavior Scale (FRSBE)
In this case, before illness refers to the time before solvent exposure

Self Rating           
                T-score                T-score
                Before Illness        %    After Illness    %
Apathy            55            69    88            >99
Disinhibition            56            73    80            >99
Executive Dysfunction    44            30    80            >99
Total                        55            69      89            >99

Interpretation: Elevated symptoms of frontal lobe damage.

Grooved Pegboard Test: Dominant Hand: Left.

                        Dominant        Non-dominant
Time for completion:                75 s            74 s
Percentile:                    22            47
Interpretation: Within normal limits

Neitz Test of Color Vision screens for color vision defects. Number correct of 9 items: 9  Interpretation:    Within normal limits

Neurotoxicity Screening Survey:               
        Factor                Results
                            Score    Classification
Memory and Concentration......     76        Elevated
Autonomic Nervous System......     62         Elevated
Vision........................             17         Elevated
Hearing.......................         10        Elevated
Balance.......................           2         Borderline elevated
Smell-Taste..................            9         Elevated
Peripheral Numbness...........         20         Elevated
Sensory-Motor.................         52         Elevated
Chemical Sensitivity.........            6         Elevated
Emotionality..................         62         Elevated
Distortion I..................       

Overall Neurotoxicity Indicator     316

Interpretation: Results are consistent with patients with diagnosed neurotoxicity.
       
Selective Reminding Test:
Words continuously remembered, summed over trials (CLTR): 36
Expected: 90
Percentile rank for gender, age and education: 7%
Interpretation: Deficit

Stroop Color and Word Test
            Raw    Age/Ed
            Score    Predicted      Residual     T-Score     Percentile
Word reading:    92        99        -7        45        31   
Color naming:    58        76        -18        35          7
Color/Word:        41        40        1        51        54
        
Interpretation:    Generally within normal limits

Visual Search and Attention Test: 
            Left        Right    Total
Score            72        69        141
Percentile        16        15         15
Interpretation:        Deficit     Deficit     Deficit

    EMOTIONAL FUNCTION

Beck Anxiety Inventory measures emotional anxiety.  Score: 33
Interpretation: Severe anxiety

Beck Depression Inventory measures emotional depression.  Score: 28
Interpretation: Moderate depression

Profile of Mood States                
                    Raw Score    T Score        %   
Tension                22         52             58
Depression**            24             48             42
Anger/Hostility          5             41             18
Vigor                  2             38             12
Fatigue             20             59             82
Confusion/Bewilderment    12             48            42

Interpretation: Mood within normal limits at time of testing. Low level of vigorous mood.

    WELL-BEING MEASURES

Alcohol Use Disorders Identification Test (AUDIT). Score: 8
Interpretation: Low-medium likelihood of alcohol problems.

Fatigue Severity Scale: Score: 46/9 = 5.1
Interpretation:    Consistent with medically ill patients

Quick Environmental Exposure and Sensitivity Inventory, Version 1 (QEESI) identifies health problems respondent may experience in response to various environmental exposures.

                        Score        Interpretation
Chemical Intolerance                26        Medium
Other Intolerance                12        Medium
Symptom Severity                53        High
Masking Index                  6        High
Life Impact                    49        High

Interpretation: Somewhat suggestive of multiple chemical intolerance.

      PERSONALITY  TESTING

Revised Neo Personality Inventory: Interpretive report: Summary

Moderately high on the factor Neuroticism, with moderately high levels of negative emotion and the occasional episodes of psychological distress. Such scorers are rather low in self-esteem and somewhat insecure.

Low in Conscientiousness, with a fairly low need for achievement and a tendency not to organize his time well.  Raters describe such people as relatively unreliable and careless.

Average range in Agreeableness, Openness, and Extroversion.

Axis II disorders: Personality disorders: Profile agreement between this respondent and the average profile for Borderline Personality Disorder is higher than 90% of subjects in the normative sample, suggesting that the patient may have Borderline features or a Borderline Personality Disorder. No other Axis II disorders were suggested or ruled out.

The respondent can be characterized as: A Gloomy Pessimist, Maladaptive (using primitive and ineffective psychological defenses; lacking insight; cannot verbalize his feelings; may be considered alexithymic (literally "without words for emotions", to describe a state of deficiency in understanding, processing, or describing emotions), Temperamental, and Under - controlled.

    DISTORTION AND MALINGERING TESTS

Amnesia Questionnaire assesses the subject's possible mis-reporting memory symptoms. Number correct of 13/13   
Interpretation:        Non-malingering   

Dot Counting Test detects suspect test-taking efforts in adults.

Comparison Group:                            Mild Dementia
Mean Ungrouped Time                                 5.5   
Mean Grouped Time                                     2.2   
Number of errors                                     0
Signs of suspect effort
Does mean Grouped time exceed mean Ungrouped time by 1 sec?        No
Are there counting errors on Card 6 and/or Card 12?            No
E-Score (# of errors plus mean time, ungrouped and group)    7.7
E-Score Cutoff                                    22
Under test development conditions:
    Sensitivity (the test's ability to detect suspect effort)            62%
    Specificity (the test's ability to detect normal effort)         94%   
Under base rate assumption of 15% population suspect effort:
Positive Predictive Accuracy    (the test's ability to detect suspect effort)    64%
Negative Predictive Accuracy(the test's ability to detect normal effort)    93%

Interpretation:    Normal effort; non-malingering

Endorsement of Rare Symptoms. The Neurotoxicity Screening Survey presents 14 symptoms that are rare. If a number of these symptoms are endorsed, the question of distortion is highlighted.

Number endorsed:    Distortion I:    3; Distortion II:    4

Interpretation: Although distortion or confusion was possible, the total distortion number was not elevated when compared with normal controls.

Memorization of "16" Items: Number correct: 16/16   
Interpretation:    Non-malingering

Miller Forensic Assessment of Symptoms Test (M-FAST)  Total score cutoff = 6. Total Interview Time: 1:45
                        % Negative    % Positive
                        Raw Score    Prediction    Prediction
Reported vs. Observed        1                   
Extreme Symptomatology        1                   
Rare Combinations            0                   
Unusual Hallucinations        0                   
Unusual Symptom Course        0                   
Negative Image            0                   
Suggestibility                1                   
Total                    3        99%        57%           
Interpretation:      Non-malingering

Portland Digit Recognition Test

    Percent correct responses (5 sec delay): 3/3   
    Percent correct responses (15 sec delay): 3/3
    Percent correct responses (30 sec delay): 1/1   

Interpretation: Non-malingering

Three Word Memory Test

Number correct: 9/9   
Interpretation:    Non-malingering   

Test of Memory Malingering (TOMM): Decision rules: 1) Scoring lower than chance on any trial indicates the possibility of malingering: Scores below 18 are unlikely to occur by chance; 2) any score lower than 45 on Trial 2 or the Retention Trial indicates the possibility of malingering.

            Raw Score       
Trial 1            31       
Trial 2            45
Retention        48       

Interpretation:     Non-malingering.

Twenty-one Item Memory Test assesses the probability of malingering based on a forced choice comparison. If the subject does not remember correctly nine of the 21 items on the forced choice test, the subject may be malingering.

Number of words correctly recalled:
    Free recall: 9        
    Forced choice: 19   
Interpretation:    Non-malingering

Recognition testing: Recognition is an easier task than recall.

Recognition test         Results            Classification

Logical Memory II        26/30            good or better effort
Verbal Paired Associates II 24/24 word pairs excellent effort
Word Lists II (min. 18)    20/24             good or better effort
Visual Reproduction II    NA    NA
Auditory recognition - Delayed (min. 43) 44 good or better effort

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